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A study of osteoporosis as it relates to metabolic manifestations in edentulous women.

Identifieur interne : 00B161 ( Main/Exploration ); précédent : 00B160; suivant : 00B162

A study of osteoporosis as it relates to metabolic manifestations in edentulous women.

Auteurs : G P Rodriquez [États-Unis] ; J. Claus-Walker ; G. Reed

Source :

RBID : pubmed:1298822

Descripteurs français

English descriptors

Abstract

Among some patients, regardless of age, the jaw loses bone mass, leading to loosening and falling out of otherwise healthy teeth. This study seeks to establish whether this bone loss is associated with the metabolic manifestations of other forms of localized decalcifications, such as in Paget's disease, or with generalized osteoporosis. Sixteen women being fitted with dental implants to compensate for bone losses provided 24-hour urine samples for the quantitative determination of calcium and galactosyl hydroxylysine, a bone collagen metabolite. These patients provided demographic information, relevant medical, dental, and dietary history, a profile of their current medications, and the status of their smoking and exercise habits. Urinary excretion of galactosyl hydroxylysine, which is increased in the presence of progressive increased bone resorption, remained within normal values in the patients of this study. These results suggest that the thinning of the jaw bones and subsequent tooth loss of these subjects were osteoporotic processes too limited and too localized to produce measurable increases in urinary bone metabolites.

PubMed: 1298822


Affiliations:


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Le document en format XML

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<nlm:affiliation>Department of Physical Medicine and Rehabilitation, Baylor College of Medicine, Houston, TX.</nlm:affiliation>
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<term>Calcium (urine)</term>
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<term>Hydroxylysine (analogues et dérivés)</term>
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<term>Loi du khi-deux</term>
<term>Oestrogènes (métabolisme)</term>
<term>Ostéoporose ()</term>
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<div type="abstract" xml:lang="en">Among some patients, regardless of age, the jaw loses bone mass, leading to loosening and falling out of otherwise healthy teeth. This study seeks to establish whether this bone loss is associated with the metabolic manifestations of other forms of localized decalcifications, such as in Paget's disease, or with generalized osteoporosis. Sixteen women being fitted with dental implants to compensate for bone losses provided 24-hour urine samples for the quantitative determination of calcium and galactosyl hydroxylysine, a bone collagen metabolite. These patients provided demographic information, relevant medical, dental, and dietary history, a profile of their current medications, and the status of their smoking and exercise habits. Urinary excretion of galactosyl hydroxylysine, which is increased in the presence of progressive increased bone resorption, remained within normal values in the patients of this study. These results suggest that the thinning of the jaw bones and subsequent tooth loss of these subjects were osteoporotic processes too limited and too localized to produce measurable increases in urinary bone metabolites.</div>
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